This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 16-22 October 2022 and includes updates on COVID-19, monkeypox, diphtheria, West Nile virus, measles, Ebola virus disease, cholera, influenza A(H5N6), poliomyelitis, seasonal influenza, and Avian influenza A(H5N1) in mink.