The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 28 February-6 March 2021 and includes updates on COVID-19, seasonal influenza, Ebola virus disease, Middle East respiratory syndrome coronavirus (MERS-CoV), cholera and influenza A (H9N2).